Effect of language-of-testing on cognitive measures Lead Investigator: Susie Henley Institution : UCL Institute of Neurology, London E-Mail : susie.henley@ucl.ac.uk Proposal ID : 502 Proposal Description: Aim: to assess what (if any) impact being tested in one???s primary language or not has on cognitive measures A) What (if any) is the difference in cognitive score (MMSE and neuropsych) between those tested in their primary language vs. those tested not in their primary language, after adjusting for demographic variables such as age, gender, education, handedness, length of symptoms, form used? B) Is this difference moderated by other factors, e.g. is there an interaction between the effect of test language and cognitive status (demented/AD vs cognitively-normal) or between effect of test language and mental health metrics such as depression (GDS) or behavioural symptoms (NPI) or clinician-judged symptoms of these? C) Does language of testing affect how cognitive scores are related to other variables, e.g. do scores from people tested in non-primary-language correlate less well with informant- or clinician-derived measures such as CDR and diagnosis than scores from people tested in primary-language (essentially testing the hypothesis that people tested in non-primary-language look worse than they really are when all other forms of information are taken into account)?